| Entry |
|
|---|
| Name |
Enalapril (INN);
Enalapril (TN) |
|---|
| Formula |
C20H28N2O5
|
|---|
| Exact mass |
376.1998
|
|---|
| Mol weight |
376.4467
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
|
|---|
| Remark |
| Product (DG00335): | D00621<JP/US> |
|
|---|
| Efficacy |
Antihypertensive, Angiotensin-converting enzyme inhibitor |
|---|
| Comment |
Active form of prodrug: Enalaprilat [CPD: C11720]
|
|---|
| Target |
|
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| Pathway |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07217 | Renin-angiotensin system inhibitors |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
C09A ACE INHIBITORS, PLAIN
C09AA ACE inhibitors, plain
C09AA02 Enalapril
D07892 Enalapril (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG00335 Enalapril
D07892 Enalapril
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
DG00335 Enalapril
D07892 Enalapril
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Peptidyl-dipeptidases
ACE (CD143)
D07892 Enalapril (INN)
Prodrugs [br08324.html]
D07892
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG00335 Enalapril
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
DG00335 Enalapril
Prodrugs [br08324.html]
DG00335
|
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| Other DBs |
|
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| KCF data |
ATOM 27
1 N1y N 30.4941 -17.9740
2 C1x C 30.4941 -16.5752
3 C5a C 29.3052 -18.6733
4 C1y C 31.8229 -18.3236
5 C1x C 31.8229 -16.0857
6 C1c C 28.1163 -17.9740
7 O5a O 29.3052 -20.0720
8 C1x C 32.6621 -17.2047
9 N1b N 26.9274 -18.6733
10 C1a C 28.0463 -16.5752
11 C1c C 25.6685 -17.9740
12 C1b C 24.4796 -18.7432
13 C7a C 25.6685 -16.5752
14 C1b C 23.2907 -18.0439
15 O7a O 24.4796 -15.9458
16 O6a O 26.8574 -15.8759
17 C8y C 22.1018 -18.7432
18 C8x C 20.8429 -18.0439
19 C8x C 19.6540 -18.7432
20 C8x C 19.6541 -20.1420
21 C8x C 20.9129 -20.8413
22 C8x C 22.1018 -20.1420
23 C1b C 23.2208 -16.6452
24 C1a C 22.0318 -16.0157
25 C6a C 31.8229 -19.7224
26 O6a O 30.5640 -20.4916
27 O6a O 33.0118 -20.4217
BOND 28
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 3 6 1
6 3 7 2
7 4 8 1
8 6 9 1
9 6 10 1 #Up
10 9 11 1
11 11 12 1
12 11 13 1 #Up
13 12 14 1
14 13 15 1
15 13 16 2
16 14 17 1
17 5 8 1
18 17 18 2
19 18 19 1
20 19 20 2
21 20 21 1
22 21 22 2
23 17 22 1
24 15 23 1
25 23 24 1
26 4 25 1 #Up
27 25 26 2
28 25 27 1
|
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